We study the different mechanisms which make a specialized artery subtype known as the collateral artery. Collateral arteries bridge conventional arteries and establish connections between two distinct arterial trees. They receive blood flow from two directions when present naturally, but act as natural bypasses in the case of primary artery occlusions. These vessels are present in the heart and brain and serve as vital conduits that increase survival rates during heart attacks or strokes. The processes underlying collateral development and formation are the subject of numerous hypotheses. To address them, we employ a diverse range of cell and molecular biology techniques such as mouse genetics, experimental injury models, whole-organ and live imaging, transcriptomics, as well as in vitro and in vivo functional assays. Using this approach, we hope to unravel the complexities of collateral artery development and understand its contribution to tissue regeneration.
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Swarnadip receives Asia-Pacific Developmental Biology Network (APDBN) and the Infosys Foundation Travel Award to attend the EMBO workshop in Kobe, Japan
Soumya receives 2024 Werner Risau Early Career Investigator Award in Vascular Biology by ATBV/AHA
Our work on artery dedifferentiation was recognized as the Most outstanding paper published during 2023 in the Vascular Biology section of the journal ATVB Congratulations to all authors & collaborators. Thanks to AHA, ATVB, Editors and Reviewers for the support! To view this article click here
Opportunities
We are always looking for enthusiastic students and postdocs with an interest to explore different aspects of vascular biology in the context of development and disease. Please write to soumyashree at ncbs dot res dot in and tell us more about what excites you the most!
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